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786 Chapter 24
Copyright © 2017 Pearson Education, Inc.
47.
The conversion of propionyl-CoA to methylmalonyl-CoA requires biotin (vitamin H).
The conversion of methylmalonyl-CoA to succinyl-CoA requires coenzyme B
12
(vitamin B
12
).
48.
In Problem 35, we saw how the carbons in d-glyceraldehyde-3-phosphate correspond to the carbons in
pyruvate.
CH
2
OPO
3
2
−
OH
HC O
H
3
2
1
CH
2
OPO
3
2
−
OH
HC O
H
4
5
6
3 and 4
2 and 5
1 and 6
C
CH
3
O
COO
−
D
-glyceraldehyde-3-phosphate
pyruvate
Now we can answer the questions. The label in pyruvate is indicated by *.
a.
C
CH
3
O
COO
−
*
b.
C
CH
3
COO
−
* O
c.
C
CH
3
O
COO
−
*
d.
C
CH
3
COO
−
*
O
e.
C
CH
3
O
COO
−
*
f.
C
CH
3
COO
−
*
O
49.
O
−
+
+
O
O
pyruvate
SCoA
O
O
−
−
O
O
O O
oxaloacetate
SCoA
CoASH
O
O HO CO
2
H
2
O
O
−
O
−
O
O
pyruvate
pyruvate
carboxylase
pyruvate
dehydrogenase
complex
acetyl-CoA
−
O
−
O
O HO CO
2
O
−
citrate
−
citrate synthase