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Chapter 24 783
Copyright © 2017 Pearson Education, Inc.
30.
the conversion of citrate to isocitrate
the conversion of fumarate to (
S
)-malate
31.
a.
the conversion of pyruvate to acetyl-CoA
b.
It is catalyzed by the pyruvate dehydrogenase complex, a group of 3 enzymes and 5 coenzymes
(pages 1076–1077 in the text).
32.
+
+
+
CoAS
ATP
ADP
CR
−
O
CoAS
CoASH
CR
H
B
a fatty acid
R
R SCoA
R
−
O
−
O
P
O
O
−
−
O
O
P
O
HO
−
−
O
O
P
O
O
−
−
+
+
BH
O
O
P
O
−
O
−
O O
P
O
−
O
O
P
Ad
O
−
O
O
P
O
O
−
O
−
O
P
Ad
O
−
O
O
P
O
_
O
_
O
B
C
O
O
C
O
C
O
33.
reduction
O
_
O
_
O
O
O
O
_
O
_
O
O
OH
a
-ketoglutarate
34.
The label will be on the phosphate group that is attached to the enzyme (phosphoglycerate mutase) that
catalyzes the isomerization of 3-phosphoglycerate to 2-phosphoglycerate.
35.
If you examine the mechanism for the isomerism of glucose-6-phosphate to fructose-6-phosphate on page
1056 of the text, you can see that C-1 in d-glucose is also C-1 in d-fructose.
Now if you examine the mechanism for the aldolase-catalyzed cleavage of fructose-1,6-bisphos-
phate to form dihydroxyacetone phosphate glyceraldehyde-3-phosphate on page 1058 of the text,
you can see which carbons in d-glucose correspond to the carbons in dihydroxyacetone phosphate and
d-glyceraldehyde-3-phosphate.