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510 Chapter 15
Copyright © 2017 Pearson Education, Inc.
88.
CH
CF
3 2
N
H C
O
CH
3
HO
−
CH C
N
C
O
OCH
2
CF
3
O
CH
3
−
CH
O
+ CF
3
CH
2
O
−
HO
−
CH
OH O
−
HO
H
CH
N
C H
O
CH
3
+
HO
−
CH C O
−
N
C H
O
CH
3
+
H
2
O
C OH
OCH
C
O
C
N
C
O
CH
3
C
N
C
O
CH
3
C
O
C
O
89.
An enzyme called penicillinase provides resistance to penicillin using its CH
2
OH group to open the
four-membered ring. (See page 714 of the text.)
CH
2
OH
N
O
CH
2
O
N
H
−
B
+
O
−
O
NH
O
CH
2