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Chapter 21 715
Copyright © 2017 Pearson Education, Inc.
H
3
NCH
CH
2
CH(CH
3
)
2
NHCH
CH
2
NHCH
CH
3
NHCH O
_
+
C
O
C
O
C
O
C
O
Leu Phe Ala Val
NHCH
CH
2
CH(CH
3
)
2
(CH
3
)
3
CO
NHCH
CH
2
1. DCCD
NHCH O
_
2. H
2
NCH O
_
CH(CH
3
)
2
NHCH
CH
2
CH(CH
3
)
2
(CH
3
)
3
CO
NHCH
CH
2
NHCH NHCH O
_
CH(CH
3
)
2
Val
CF
3
CO
2
H CH
2
Cl
2
C
O
C
O
C
O
C
O
C
O
C
O
C
O
C
O
C
O
C
O
CH
3
CH
3
CH
3
C
CH
2
CO
+
+
2
CH
3
CH(CH
3
)
2
35.
Notice that the number of steps is one less than the number of amino acids in the peptide.
a.
5.8%
2
3
4
5
6
7
8
9
70% 49% 34% 24% 17% 12% 8.2% 5.8%
b.
4.4%
2 3 4 5 6 7 8 9 10 11 12 13 14 15
80% 64% 51% 41% 33% 26% 21% 17% 13% 11% 8.6% 6.9% 5.5% 4.4%