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Chapter 23 767
Copyright © 2017 Pearson Education, Inc.
28.
The product of transamination of an amino acid has a carbonyl group in place of the amino group.
a.
derived from Val
derived from Leu
derived from Ile
_
C
CH
3
CH
C
O
O
O
CH
3
_
C
CH
3
CHCH
2
C
O
O
O
_
O
CH
3
C
CH
3
CH
2
CH
C
O
O CH
3
b.
SCoA
CH
3
CH
C
O
CH
3
SCoA
CH
3
CHCH
2
C
O
CH
3
SCoA
CH
3
CH
2
CH
C
O
CH
3
c.
The reaction catalyzed by
a
-keto acid dehydrogenase is identical to the reaction catalyzed by the
pyruvate dehydrogenase complex (Section 23.3). Therefore, they both require the same coenzymes:
thiamine pyrophosphate, lipoate, coenzyme A,
FAD, NAD
+
.
d.
The disease can be treated by a diet low in branched-chain amino acids.
29.
_
CH
3
HOCH
2
OOCCH
2
CH
2
CH
3
CH
2
CH
CH
3
CHCH
2
CH
3
CH
CH
3
CH
3
CH
3
C
O
C
O
C
O
C
O
C
O
C
O
30.
COO
−
C H
C
SCoA
CH
3
O
COO
−
C H
C
SCoA
CH
2
H
O
AdCH
2
Co(III)
AdCH
2
Co(II)
•
AdCH
2
Co(II)
AdCH
2
Co(II)
•
H
AdCH
2
Co(III)
COO
−
C H
C
SCoA
CH
2
O
AdCH
3
Co(II)
•
•
COO
−
C H
C
SCoA
CH
2
O
COO
−
CH
2
C
SCoA
CH
2
O